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Oral Fluoroquinolone Use Not Linked to Retinal Detachment

Findings in large Danish cohort for current use, recent use, past use, distant use
TUESDAY, Nov. 26, 2013 (HealthDay News) -- Oral fluoroquinolone use is not associated with the risk of retinal detachment, according to a Danish cohort study published in the Nov. 27 issue of the Journal of the American Medical Association.
Björn Pasternak, M.D., Ph.D., from the Statens Serum Institut in Copenhagen, Denmark, and colleagues conducted a nationwide, register-based cohort study in Denmark to examine whether oral fluoroquinolone use is associated with an increased risk of retinal detachment. The cohort included 748,792 episodes of fluoroquinolone use and 5,520,446 control episodes of nonuse.
The researchers identified 566 cases of retinal detachment, of which 82 percent were rhegmatogenous detachments. Seventy-two cases occurred in fluoroquinolone users, while 494 occurred in control nonusers. The risk of retinal detachment was not significantly increased with fluoroquinolone use compared to nonuse, with adjusted relative risks of 1.29 (95 percent confidence interval [CI], 0.53 to 3.13) for current use; 0.97 (95 percent CI, 0.46 to 2.05) for recent use; 1.37 (95 percent CI, 0.80 to 2.35) for past use; and 1.27 (95 percent CI, 0.93 to 1.75) for distant use. For current use, the absolute risk difference, estimated as the adjusted number of retinal detachment cases per 1,00,00 treatment episodes, was 1.5 (95 percent CI, −2.4 to 11.1).
"In this cohort study based on the general Danish population, oral fluoroquinolone use was not associated with increased risk of retinal detachment," the authors write.
Abstract (http://jama.jamanetwork.com/article.aspx?articleid=1785461#Abstract )Full Text (subscription or payment may be required) (http://jama.jamanetwork.com/article.aspx?articleid=1785461 )Editorial (subscription or payment may be required) (http://jama.jamanetwork.com/article.aspx?articleid=1785435 )
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