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Salt-Containing Rx Formulations Increase Cardiovascular Risk

Higher risk largely due to stroke and hypertension
WEDNESDAY, Nov. 27, 2013 (HealthDay News) -- People taking sodium-containing formulations of drugs are at higher risk of cardiovascular events, particularly stroke and hypertension, according to a study published online Nov. 26 in BMJ.
Jacob George, M.D., from Ninewells Hospital in Dundee, U.K., and colleagues examined the composite risk of non-fatal myocardial infarction, incident non-fatal stroke, or vascular death in 1,292,337 adult patients who were prescribed at least two prescriptions of sodium-containing effervescent, dispersible, and soluble drug formulations or matched standard formulations of the same drug.
During a mean follow-up of 7.23 years, the researchers found that 61,072 patients had an incident cardiovascular event. After adjusting for various factors, the composite risk of incident non-fatal myocardial infarction, incident non-fatal stroke, or vascular death was higher among those taking sodium-containing formulations (odds ratio [OR], 1.16). Sodium-containing formulations were also associated with a higher risk of incident non-fatal stroke (OR, 1.22), all-cause mortality (OR, 1.28), and hypertension (OR, 7.18), but no increased risk of heart failure, incident non-fatal myocardial infarction, or vascular death. The median time from first prescription to first event was 3.92 years.
"Exposure to sodium-containing formulations of effervescent, dispersible, and soluble medicines was associated with significantly increased odds of adverse cardiovascular events compared with standard formulations of those same drugs," George and colleagues conclude.
Full Text (http://www.bmj.com/content/347/bmj.f6954 )
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