About Us  |  Contact Us  |  Español
VNA of Care New England
VNA of Care New England

Drugs Show Similar Efficacy in Metastatic Kidney Cancer

But pazopanib has better safety and quality of life
WEDNESDAY, Aug. 21 (HealthDay News) -- While pazopanib and sunitinib are similarly effective in patients with metastatic renal-cell cancer, pazopanib is associated with better safety and quality of life, according to a study published in the Aug. 22 issue of the New England Journal of Medicine.
As part of a phase 3, open-label study, Robert J. Motzer, M.D., from the Memorial Sloan-Kettering Cancer Center in New York City, and colleagues randomly assigned 1,110 patients with clear-cell, metastatic renal-cell carcinoma to pazopanib (800 mg daily) or sunitinib in six-week cycles (50 mg daily for four weeks, no treatment for two weeks) as a first-line treatment.
The researchers found that pazopanib and sunitinib offered similar progression-free survival (hazard ratio for progression, 1.05) and overall survival (hazard ratio for death, 0.91). Pazopanib treatment was associated with significantly better improvement on 11 of 14 health-related quality-of-life domains during the first six months of treatment. Pazopanib treatment was associated with a greater incidence of elevated alanine aminotransferase, while sunitinib treatment was associated with a greater incidence of fatigue, hand-foot syndrome, and thrombocytopenia.
"Pazopanib and sunitinib have similar efficacy, but the safety and quality-of-life profiles favor pazopanib," Motzer and colleagues conclude.
The study was funded by GlaxoSmithKline, the manufacturer of pazopanib; several authors are employees of the company.
Full Text (subscription or payment may be required) (http://www.nejm.org/doi/full/10.1056/NEJMoa1303989 )
Health Headlines
FDA Approves HPV Test as Initial Screen for Cervical CancerView in a lightbox
FDA Proposes E-Cigarette RegulationsView in a lightbox
FDA Reconsiders Behavior-Modifying 'Shock Devices'View in a lightbox
Genetic Code of Tsetse Fly May Help Fight Sleeping SicknessView in a lightbox
Workplace Ladder Falls a Major Cause of Deaths, Injuries: CDCView in a lightbox
VNA of Care New England
© 2011 Site Index | Disclaimer | Legal Notices