Score Predicts 10-Year Risk of Dementia in Type 2 Diabetes
Score includes presence of diabetic foot disease, age, education, depression, and vascular disease
TUESDAY, Aug. 20 (HealthDay News) -- A risk score has been created and validated to predict the 10-year risk of dementia among patients with type 2 diabetes, according to a study published online Aug. 20 in The Lancet Diabetes & Endocrinology.
Lieza G. Exalto, M.D., from the Medical Center Utrecht in the Netherlands, and colleagues used data from two longitudinal cohorts of patients with type 2 diabetes aged 60 years and older, with 10 years of follow-up, to create and validate a summary risk score that could be used to estimate the 10-year dementia risk. The creation and validation cohorts included 29,961 and 2,413 patients, respectively.
The researchers found that microvascular disease, diabetic foot disease, cerebrovascular disease, cardiovascular disease, acute metabolic events, depression, age, and education were the factors most strongly predictive of dementia (C statistics, 0.736 for creation cohort and 0.746 for validation cohort) and included them in the risk score. The dementia risk for the lowest and highest sum scores was 5.3 and 73.3 percent, respectively.
"To the best of our knowledge, this is the first risk score for the prediction of 10-year dementia risk in patients with type 2 diabetes mellitus," the authors write. "The risk score can be used to increase vigilance for cognitive deterioration and for selection of high-risk patients for participation in clinical trials."
One author disclosed financial ties to the pharmaceutical industry.
Abstract (http://www.thelancet.com/journals/landia/article/PIIS2213-8587(13)70048-2/abstract )Full Text (subscription or payment may be required) (http://www.thelancet.com/journals/landia/article/PIIS2213-8587(13)70048-2/fulltext )Editorial (subscription or payment may be required) (http://www.thelancet.com/journals/landia/article/PIIS2213-8587(13)70091-3/fulltext )