About Us  |  Contact Us  |  Español
VNA of Care New England
VNA of Care New England

High-Altitude Pilots Have More White Matter Hyperintensities

In pilots, white matter hyperintensities are uniformly distributed throughout brain
MONDAY, Aug. 19 (HealthDay News) -- Pilots of U-2 high-altitude reconnaissance aircraft with occupational exposure to hypobaria show a significant increase in both the number of and volume of white matter hyperintensities (WMH), according to a study published in the Aug. 20 issue of Neurology.
Stephen McGuire, M.D., from the U.S. Air Force School of Aerospace Medicine at the Wright-Patterson Air Force Base in Ohio, and colleagues evaluated 102 U-2 pilots and 91 matched controls using three-dimensional, T2-weighted, high-resolution (1-mm isotropic) imaging data.
The researchers found that U-2 pilots demonstrated a significant increase in volume (394 percent) and number (295 percent) of WMH. WMH were more uniformly distributed throughout the brain in U-2 pilots compared with the mainly frontal distribution in controls.
"This is consistent with our hypothesized pattern of damage produced by interaction between microemboli and cerebral tissue, leading to thrombosis, coagulation, inflammation, and/or activation of innate immune response, although further studies will be necessary to clarify the pathologic mechanisms responsible," the authors write.
Abstract (http://www.neurology.org/content/81/8/729.abstract )Full Text (subscription or payment may be required) (http://www.neurology.org/content/81/8/729.full )
Health Headlines
Two Drugs Work Equally Well for Epileptic Seizures in Kids: StudyView in a lightbox
For Teen Drivers, Unruly Passengers May Be Greater Threat Than PhonesView in a lightbox
Glaucoma Drug May Help Reverse Obesity-Related Vision LossView in a lightbox
Certain Type of Brain Malformation May Be Best Left AloneView in a lightbox
Could Cow Fertilizer Help Spread Antibiotic Resistance?View in a lightbox
VNA of Care New England
© 2011 Site Index | Disclaimer | Legal Notices