Increased Phthalates Up Insulin Resistance in Teens
Second study shows higher BPA levels linked to obesity, waist-to-height ratio in children
MONDAY, Aug. 19 (HealthDay News) -- Increased urinary phthalates are associated with increased insulin resistance in adolescents; and higher bisphenol A (BPA) levels are associated with obesity and abnormal waist circumference-to-height ratio in children, according to two studies published online Aug. 19 in Pediatrics.
Leonardo Trasande, M.D., M.P.P., from New York University in New York City, and colleagues used cross-sectional-data from 766 fasting youth (aged 12 to 19 years) from the National Health and Nutrition Examination Survey (NHANES) 2003 to 2008 to examine the correlations of phthalate metabolites with measures of homeostatic model assessment of insulin resistance (HOMA-IR). The researchers found that after adjustment for confounding variables there was a 0.27 increase in HOMA-IR with each log increase in di-2-ethylhexylphthalate metabolites. The correlation persisted even after controlling for BPA.
Donna S. Eng, M.D., from the University of Michigan in Ann Arbor, and colleagues used NHANES 2003 to 2008 data to examine the correlation between urinary BPA levels and measures of adiposity, cholesterol, insulin, and glucose among 6- to 18-year-olds. The researchers found that the odds of obesity were higher with increasing quartiles of BPA (quartiles 2, 3, and 4 versus 1 odds ratios, 1.74, 1.64, and 2.01, respectively). The odds of an abnormal waist circumference-to-height ratio were also increased (quartiles 2, 3, and 4 versus 1 odds ratios, 1.37, 1.41, and 1 55, respectively). There were no significant associations between BPA and other chronic disease risk factors.
"Longitudinal analyses are needed to elucidate temporal relationships between BPA exposure and the development of obesity and chronic disease risk factors in children," Eng and colleagues conclude.
Abstract - Trasande (http://pediatrics.aappublications.org/content/early/2013/08/13/peds.2012-4022.abstract )Full Text (subscription or payment may be required) (http://pediatrics.aappublications.org/content/early/2013/08/13/peds.2012-4022.full.pdf+html )Abstract - Eng (http://pediatrics.aappublications.org/content/early/2013/08/13/peds.2013-0106.abstract )Full Text (subscription or payment may be required) (http://pediatrics.aappublications.org/content/early/2013/08/13/peds.2013-0106.full.pdf+html )Editorial (subscription or payment may be required) (http://pediatrics.aappublications.org/content/early/2013/08/13/peds.2013-2054.full.pdf+html )