Taller Postmenopausal Women at Higher Risk for Cancer
Greater height was linked with increased risk of all cancers and specific cancers at numerous sites
THURSDAY, July 25 (HealthDay News) -- For postmenopausal women, height is positively associated with risk of all cancers and risk of specific cancers at numerous sites, according to research published online July 25 in Cancer Epidemiology, Biomarkers & Prevention.
Geoffrey C. Kabat, M.D., of the Albert Einstein College of Medicine in Bronx, N.Y., and colleagues analyzed data for 144,701 women participating in the Women's Health Initiative. The association between height measured at enrollment and risk of all cancers and risk of specific cancers at 19 sites was assessed.
The researchers found that height was positively associated with risk of all cancers (hazard ratio [HR], 1.13). Height also was positively linked with risk of cancers of the breast; colon, colorectum, and rectum; endometrium; kidney; ovary; and thyroid; and with melanoma and multiple myeloma. Neither confounding nor effect modification appeared to contribute to these associations.
"Further elucidation of the function of the genetic loci associated with height may help to clarify possible mechanisms underlying the associations of height with specific cancers," the authors write.
Abstract (http://cebp.aacrjournals.org/content/early/2013/07/25/1055-9965.EPI-13-0305.abstract )Full Text (subscription or payment may be required) (http://cebp.aacrjournals.org/content/early/2013/07/25/1055-9965.EPI-13-0305.full.pdf+html )