About Us  |  Contact Us  |  Español
VNA of Care New England
VNA of Care New England

Review: All Approved Drugs Similarly Prevent Migraines

Off-label angiotensin-inhibiting drugs and beta-blockers have favorable benefit-to-harm ratios
THURSDAY, April 25 (HealthDay News) -- There is no significant difference in effectiveness in approved drugs for preventing episodic migraine frequency by 50 percent or more, according to a review published in the April issue of the Journal of General Internal Medicine.
Tatyana A. Shamliyan, M.D., from the University of Minnesota in Minneapolis, and colleagues conducted a literature review to identify randomized controlled trials (RCTs) of preventive drugs versus placebo or active treatments examining rates of ≥50 percent reduction in monthly migraine frequency or improvement in quality of life.
Based on 215 published RCTs, the researchers found that placebo was outperformed by all approved drugs, including topiramate (nine RCTs), divalproex (three RCTs), timolol (three RCTs), and propranolol (four RCTs); off-label beta blockers metoprolol (four RCTs), atenolol (one RCT), nadolol (one RCT), and acebutolol (one RCT); angiotensin-converting enzyme inhibitors captopril (one RCT) and lisinopril (one RCT); and angiotensin II receptor blocker candesartan (one RCT), in reducing monthly migraine frequency by 50 percent or more in 200 to 400 patients per 1,000 treated. Topiramate, off-label antiepileptics, and antidepressants had higher levels of adverse events, leading to treatment discontinuation. While there were no statistically significant differences in benefits between approved drugs, off-label angiotensin-inhibiting drugs and beta-blockers were the most effective and tolerable for episodic migraine prevention.
"Evidence is lacking for long-term effects of drug treatments (i.e., trials of more than three months duration), especially for quality of life," the authors write.
Abstract (http://link.springer.com/article/10.1007/s11606-013-2433-1 )Full Text (subscription or payment may be required) (http://link.springer.com/article/10.1007/s11606-013-2433-1 )
Health Headlines
Two Drugs Work Equally Well for Epileptic Seizures in Kids: StudyView in a lightbox
For Teen Drivers, Unruly Passengers May Be Greater Threat Than PhonesView in a lightbox
Glaucoma Drug May Help Reverse Obesity-Related Vision LossView in a lightbox
Certain Type of Brain Malformation May Be Best Left AloneView in a lightbox
Could Cow Fertilizer Help Spread Antibiotic Resistance?View in a lightbox
VNA of Care New England
© 2011 Site Index | Disclaimer | Legal Notices