About Us  |  Contact Us  |  Español
VNA of Care New England
VNA of Care New England

Severe Cutaneous Adverse Rxns Up in Allopurinol Initiators

SCARs are rare; usually occur within first 180 days of initiating treatment
TUESDAY, April 23 (HealthDay News) -- Allopurinol initiators have an almost 10-fold increased risk of severe cutaneous adverse reactions (SCARs) compared with nonusers, according to a study published in the April issue of Arthritis Care & Research.
Seoyoung C. Kim, M.D., from Brigham and Women's Hospital in Boston, and colleagues conducted a propensity-score matched cohort study using data from five large Medicaid programs to examine the incidence rate and in-hospital mortality of hospitalization for SCARs in allopurinol initiators compared with non-allopurinol users.
During 65,625 person-years of follow-up for allopurinol initiators, the researchers found that 45 patients were hospitalized for SCARs, with a crude incidence ratio of 0.69 per 1,000 person-years. All cases occurred within 365 of initiating treatment with allopurinol and 91.1 percent occurred within 180 days. During the hospitalization, 26.7 percent of patients died. For non-allopurinol users, the crude incidence rate was 0.04 per 1,000 person-years. For allopurinol initiators versus nonusers, the risk of SCARs was significantly increased (hazard ratio, 9.68). After adjustment for age, comorbidities, and recent diuretic use, the hazard ratio for high-dosage (>300 mg/day) versus low-dosage allopurinol was 1.30 for allopurinol users.
"Our study suggests that the risk of SCARs was 10 times as high in allopurinol initiators as compared to non-allopurinol users," the authors write. "Future studies using a large detailed clinical data set from a large prospective inception cohort of allopurinol users is needed for a better understanding of other risk factors of SCARs such as impaired renal function and concomitant medication use."
Several authors disclosed financial ties to pharmaceutical companies, including Takeda, which partially funded the study.
Abstract (http://onlinelibrary.wiley.com/doi/10.1002/acr.21817/abstract )Full Text (subscription or payment may be required) (http://onlinelibrary.wiley.com/doi/10.1002/acr.21817/full )
Health Headlines
If Kids Think Someone's Watching, They're More Likely to Wash Their HandsView in a lightbox
Spring Cleaning Safety TipsView in a lightbox
Ragwitek Approved for Adult Ragweed AllergyView in a lightbox
Restaurants in Poor Areas Push Unhealthy Foods, Study FindsView in a lightbox
Certain Sedatives Tied to Breathing Problems in Older COPD PatientsView in a lightbox
VNA of Care New England
© 2011 Site Index | Disclaimer | Legal Notices