Conditions InDepth: Peripheral Artery Disease (PAD)
Peripheral artery disease (PAD) is damage or disease of the arteries outside of the heart and brain. Blood delivers oxygen and nutrients to hardworking organs and tissues through all of the body's arteries. Injuries to the arteries can interrupt this blood flow, and impair delivery of nutrients and oxygen. Impaired blood flow can affect the health of tissue in the arms, legs, and body core. Severe interruptions in blood flow can cause functional problems, such as cramping or fatigue with minor activity.
Prolonged, untreated PAD can lead to serious complications such as death of affected tissue, serious infection, and
. Factors that cause PAD can also affect blood vessels in heart and brain. This means people with PAD also have an increased risk of
About peripheral artery disease (PAD). American Heart Association
website. Available at:
http://www.heart.org/HEARTORG/Conditions/More/PeripheralArteryDisease/About-Peripheral-Artery-Disease-PAD%5FUCM%5F301301%5FArticle.jsp. Updated September 13, 2012. Accessed June 20, 2014.
Hills AJ, Shalhoub J, et al. Peripheral arterial disease. Br J Hosp Med (Lond). 2009;70(10):560-565.
Jurado JA, Bashir R, et al. Radiation-induced peripheral artery disease. Catheter Cardiovasc Interv. 2008;72(4):563-568.
Peripheral arterial disease (PAD) of lower extremities. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T114200/Peripheral-arterial-disease-PAD-of-lower-extremities. Updated August 11, 2016. Accessed September 23, 2016.
What causes peripheral arterial disease? National Heart, Lung, and Blood Institute website. Available at:
http://www.nhlbi.nih.gov/health/health-topics/topics/pad/causes.html. Updated June 2, 2014. Accessed June 20, 2014.
What is peripheral arterial disease? National Heart, Lung, and Blood Institute website. Available at:
http://www.nhlbi.nih.gov/health/health-topics/topics/pad. Updated June 2, 2014. Accessed June 20, 2014.